Drug and protein delivery by polymer conjugation has open new pathway of research. It is important to remember that the development of complex coupling strategies such as glycoPEGylation, a double-step enzymatic approach which generates conjugates, was considered impossible only a few decades ago. In the same way, what is now considered too complex or unsuitable for further investigation may Rapid conjugation of nanoparticles, proteins and siRNAs to microbubbles by strain-promoted click chemistry for ultrasound imaging and drug delivery† Xifeng Liu , ab Ping Gong , c Pengfei Song , c Feng Xie , d A. Lee Miller II , b Shigao Chen c and Lichun Lu * ab To develop a simple alternative toward FA-mediated enhanced anticancer drug delivery, a combination strategy of micelle complex and reducible conjugation was reported in this study. FA was first conjugated to the terminus of the hydrophilic block of a reduction-sensitive miktoarm star-shaped amphiphilic copolymer, PCL3-SS-POEGMA1, with the previously optimized star structure by click coupling Nanomedicine is, generally, the application of nanotechnology to medicine. The term nanomedicine includes monitoring, construction of novel drug delivery systems, and any possible future applications of nanotechnology and nanovaccinology. In this review, the most important ligand-nanocarrier and drug-nanocarrier bioconjugations are described. The detailed characterizations of covalently formed J Drug Target. 1999;7(3):157-69. Folate-mediated drug delivery: effect of alternative conjugation chemistry. Leamon CP(1), DePrince RB, Hendren RW. Author information: (1)Department of Oligomer Development, GlaxoWellcome Research Institute, Research Triangle Park, NC 27709, USA. [email protected] When utilized as a macromolecular drug targeting ligand, folic acid (Pte-Glu) has traditionally Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery. Sobot D(1), Mura S(1), Yesylevskyy SO(2), Dalbin L(1), Cayre F(1), Bort G(1), Mougin J(1), Desmaële D(1), Lepetre-Mouelhi S(1), Pieters G(3), Andreiuk B(4)(5), Klymchenko AS(4), Paul JL(6)(7), Ramseyer C(8), Couvreur P(1). Author information: (1)Institut Galien Paris-Sud, UMR 8612 Moreover, this review will analyze the advantages and disadvantages of such chemical modifications and how they impact the pharmacological properties of aptamers. Finally, this review will summarize the conjugation strategies of aptamers to nanocarriers for developing targeted drug delivery systems. Failures of disulfide conjugation chemistry. Early thiol conjugation methods involved a direct coupling to thiol moieties present on the therapeutic. Antibodies known as thiomabs consisting of one or two cysteine residues have been developed to assist in this type of drug conjugation [9,10]. While this is an elegant way to generate conjugates via site-specific conjugation, the process to Disulfide conjugation chemistry: a mixed blessing for therapeutic drug delivery? Editorial cells and proved very effective. By contrast, a lysosome-processed lysine maleimido–maytansinoid derivative demonstrated very low cell killing potency [21]. Self-immolative disulfide linkers used in antibody– drug conjugates have also been applied as side chain linkers in polymer–drug conjugates To leverage the insights from prior studies on albumin-drug complexes and improve upon existing in situ binding and conjugation strategies, in this study, a highly potent anti-tubulin drug MMAE was pre-conjugated to albumin at controlled ratios to harness the existing advantages of albumin as a drug delivery carrier. Intact albumin-drug conjugate was delivered to ensure drug molecules were
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